Beyond the Acne

Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) is a relatively rare often underdiagnosed disorder characterized by chronic inflammation affecting the bones, joints, skin. While precise cause of SAPHO syndrome remains elusive, multiple factors such as genetics, immunological dysregulation, bacterial influences have been implicated in its pathogenesis. One notable aspect wide variability symptoms experienced afflicted individuals. A diverse array osteoarticular manifestations may be observed, with common sites involvement including anterior chest wall, sacroiliac peripheral joints. Concurrently, patients present various skin disorders, palmoplantar pustulosis or further adding to complexity syndrome's clinical presentation. Treatment strategies for primarily focus on managing improving quality life affected Nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, methotrexate (MTX), tumor necrosis factor (TNF) inhibitors are considered modulate immune response provide relief. challenges encountered diagnosing potential overlap other related conditions, leading diagnostic confusion difficulties. Distinguishing from similar entities can complex, requiring comprehensive evaluation features, imaging studies, laboratory investigations. We would like share an intriguing case involving 28-year-old woman who arrived perplexing pain her bilateral hands feet, lower back, acne upper arms thighs. Through workup, underlying was uncovered, it effectively managed using adalimumab.